产品
编 号：F330894
分子式：C15H13N3OS2
分子量：315.41
分子式：C15H13N3OS2
分子量：315.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 348575-88-2
产品详情
生物活性：
Optovin is a reversible photoactivated TRPA1 ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues.
体内研究：
Optovin (1-10 μM) causes light-dependent motor excitation in vivo.Optovin (15 mM (20 μL); on the ear) elicits nociceptive behaviors in adult mice.Optovin (10 μM; 96 h) do not affect the appearance, touch response, heart rate, fin movements, morphology or percentage survival of larvae and adult zebrafish.
体外研究：
Optovin (1-10 μM) increases Zebrafish embryos motor activity greater than 40 standard deviations above the control mean at the photic stimuli, with an EC50 of 2 μM.Optovin (100 μM; 120 s) strongly activates 33% (35/105) of dorsal root ganglia (DRG) neurons.Optovin (10 μM; 1 min) activates HEK293T cells transfected with hTrpA1.
Optovin is a reversible photoactivated TRPA1 ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues.
体内研究：
Optovin (1-10 μM) causes light-dependent motor excitation in vivo.Optovin (15 mM (20 μL); on the ear) elicits nociceptive behaviors in adult mice.Optovin (10 μM; 96 h) do not affect the appearance, touch response, heart rate, fin movements, morphology or percentage survival of larvae and adult zebrafish.
体外研究：
Optovin (1-10 μM) increases Zebrafish embryos motor activity greater than 40 standard deviations above the control mean at the photic stimuli, with an EC50 of 2 μM.Optovin (100 μM; 120 s) strongly activates 33% (35/105) of dorsal root ganglia (DRG) neurons.Optovin (10 μM; 1 min) activates HEK293T cells transfected with hTrpA1.
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