产品
编 号:F330891
分子式:C22H26BrNO3
分子量:432.35
产品类型
结构图
CAS No: 3485-62-9
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生物活性:
Clidinium bromide is a quaternary amine antimuscarinic agent. Clidinium bromide may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines in vivo.
体内研究:
Clidinium (oral gavage; 0.25, 0.5, and 1 mg/kg; 3 days) causes constipation in mice. It leads to a significant decrease in %transit after clidinium treatment [(F(3, 28)=27.405] in mice.Clidinium (oral gavage; 0.25, 0.5, and 1 mg/kg; 3 days) has a significant effect on the clonic seizure threshold induced by intravenous PTZ which received clidinium (0.25, 0.5, and 1 mg/kg) [(F(3, 35) = 14.103].Animal Model:Male NMRI mice weighing 20-25 g
Dosage:0.25, 0.5, and 1 mg/kg
Administration:Oral gavage; 0.25, 0.5, and 1 mg/kg; 3 days
Result:Decreased the clonic seizure latency compared with control animals.