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编 号：F330181
分子式：C21H29N5O2
分子量：383.49
分子式：C21H29N5O2
分子量：383.49
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CAS No: 346673-06-1
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生物活性：
TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases.
体内研究：
TCS 2510 (0.1~10 mg/kg; p.o.) produces a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration.TCS 2510 (10 mg/kg; p.o.) increases plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels.TCS 2510 (1~10 mg/kg; p.o) affords a significant elevation in plasma glucagon like peptide 2 levelsAnimal Model:Mice
Dosage:0.1~10 mg/kg
Administration:P.o.
Result:Produced a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration.
Animal Model:Mice
Dosage:10 mg/kg
Administration:P.o.
Result:Increased plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels.
Animal Model:Mice
Dosage:1~10 mg/kg
Administration:P.o.
Result:Afforded a significant elevation in plasma glucagon like peptide 2 levels.
体外研究：
TCS 2510 (0.001~100 μM; GLUTag cells) stimulates glucagon like peptide 1 secretion. TCS2510 activates the Gas signaling pathway. TCS 2510 (10 μM; 2~24 h; GLUTag cells) increases the Gcg mRNA expression levels. TCS 2510 produces a concentration dependent increase in cAMP levels in GLUTag cells with EC50 of 20 nM and the maximal stimulation of 60 % over the basal cAMP levels. The decrease in cell impedance in GLUTag cells observed with TCS 2510 is concentration dependent with IC50 of 15 nM. TCS 2510 produces a concentration-dependent increase in glucagon like peptide 2 secretion in GLUTag cells.
TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases.
体内研究：
TCS 2510 (0.1~10 mg/kg; p.o.) produces a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration.TCS 2510 (10 mg/kg; p.o.) increases plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels.TCS 2510 (1~10 mg/kg; p.o) affords a significant elevation in plasma glucagon like peptide 2 levelsAnimal Model:Mice
Dosage:0.1~10 mg/kg
Administration:P.o.
Result:Produced a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration.
Animal Model:Mice
Dosage:10 mg/kg
Administration:P.o.
Result:Increased plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels.
Animal Model:Mice
Dosage:1~10 mg/kg
Administration:P.o.
Result:Afforded a significant elevation in plasma glucagon like peptide 2 levels.
体外研究：
TCS 2510 (0.001~100 μM; GLUTag cells) stimulates glucagon like peptide 1 secretion. TCS2510 activates the Gas signaling pathway. TCS 2510 (10 μM; 2~24 h; GLUTag cells) increases the Gcg mRNA expression levels. TCS 2510 produces a concentration dependent increase in cAMP levels in GLUTag cells with EC50 of 20 nM and the maximal stimulation of 60 % over the basal cAMP levels. The decrease in cell impedance in GLUTag cells observed with TCS 2510 is concentration dependent with IC50 of 15 nM. TCS 2510 produces a concentration-dependent increase in glucagon like peptide 2 secretion in GLUTag cells.
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