产品
编 号:F038194
分子式:C30H50
分子量:410.72
产品类型
结构图
CAS No: 111-02-4
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产品详情
生物活性:
Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity.
体内研究:
Squalene(0.25-1 g/kg;饲喂饲料;饮食持续 11 周)可促进 HDL- 胆固醇和对氧磷酶 1 的变化,并降低脂蛋白中的活性氧和血浆丙二醛水平。Animal Model:Male mouse models (wild-type, Apoa1- and Apoe- deficient)
Dosage:0.25 g/kg, 1 g/kg
Administration:Fed chow; diets for 11 weeks
Result:Increased high density lipoprotein-cholesterol and paraoxonase 1 and decreases oxidative stress in mice.
体外研究:
Squalene(12.5、50 和 200 μM;24 小时)以剂量依赖性方式对 MCF10A 上皮细胞产生影响:(a) 降低细胞内 ROS 水平,(b) 防止 H2O2 诱导的氧化损伤,(c) 保护 对抗 DNA 氧化损伤。