产品
编 号:F330138
分子式:C20H29N5O3
分子量:387.48
产品类型
结构图
CAS No: 34661-75-1
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产品详情
生物活性:
Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.
体外研究:
Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist. Urapidil does not affect vascular tone at concentrations up to 10-5 M. Urapidil (10-5 M) markedly inhibits the alpha 1-adrenergic agonist (phenylephrine)-induced concentration-dependent contractions in aortic rings without endothelium and also to some extent in those with endothelium. Moreover, the inhibitory effect of Urapidil is more pronounced in rings without endothelium than in those with endothelium. Urapidil (10-5 M) affects neither the vascular tone nor the concentration-dependent contraction to serotonin.