产品
编 号：F329697
分子式：C48H78O20
分子量：975.12
分子式：C48H78O20
分子量：975.12
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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50mg
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100mg
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200mg
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结构图
CAS No: 34540-22-2
产品详情
生物活性：
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects.Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB, exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity. Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.
体内研究：
Madecassosid (6，12，24 mg/kg，i.v) 修复病灶性大脑缺血再灌注造成的神经元损伤，并改善了神经元凋亡。Madecassosid (6，12，24 mg/kg，i.v) 抑制 NF-kB 的活性以抑制大脑损伤。Madecassosid (120 mg/kg，i.g.) 通过上调 Nrf2 的表达来降低 LPS 诱导产生的神经毒性并且提高了血红素加氧酶蛋白的表达。。Madecassosid (10-40 mg/kg, p.o.) 改善了博来霉素 (BLM) 灌注后引发的氧化损伤和炎症，抑制 TGF-β1 过表达和胶原合成，提高胶原降解。。Animal Model:Focal cerebral ischemia reperfusion injury in Sprague Dawley rats
Dosage:6, 12, 24 mg/kg
Administration:Intravenous injection
Result:Reduced neurological deficit, infarct area, brain damage and neuronal apoptosis.
Animal Model:Lipopolysaccharide-induced neurotoxicity in Sprague-Dawley rats
Dosage:30-120 mg/kg for 14 days
Administration:Intraperitoneal injection
Result:Reduced LPS-induced cognitive impairment and imflammatory cytokine, promoted Nrf2 pathway at concentration of 120 mg/kg.
体外研究：
Madecassosid (30，100 μM，12 h) 增强了氧化应激损伤的 HUVECs 细胞的细胞活力。Madecassosid (10-100 μM，12 h) 抑制 p38 MAPK 的磷酸化和 Caspase-3 的活性，从而表达出抗凋亡活性。Madecassosid (10-100 μg/L) 对于黑色素细胞的树突收缩展现出抗氧化活性，并且能够维持线粒体膜电位和 Ca2+ 稳态。Madecassosid (30 μM) 通过增加 p-IRS1，Akt 和 p-Akt 在糖毒条件下的表达，提高了胰岛素的分泌。Madecassosid (10 μM，24 h) 通过 III-PI3K/Beclin-1/Bcl-2 通路，抑制Aβ25–35 诱导的神经细胞炎症和自噬反应。
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects.Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB, exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity. Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.
体内研究：
Madecassosid (6，12，24 mg/kg，i.v) 修复病灶性大脑缺血再灌注造成的神经元损伤，并改善了神经元凋亡。Madecassosid (6，12，24 mg/kg，i.v) 抑制 NF-kB 的活性以抑制大脑损伤。Madecassosid (120 mg/kg，i.g.) 通过上调 Nrf2 的表达来降低 LPS 诱导产生的神经毒性并且提高了血红素加氧酶蛋白的表达。。Madecassosid (10-40 mg/kg, p.o.) 改善了博来霉素 (BLM) 灌注后引发的氧化损伤和炎症，抑制 TGF-β1 过表达和胶原合成，提高胶原降解。。Animal Model:Focal cerebral ischemia reperfusion injury in Sprague Dawley rats
Dosage:6, 12, 24 mg/kg
Administration:Intravenous injection
Result:Reduced neurological deficit, infarct area, brain damage and neuronal apoptosis.
Animal Model:Lipopolysaccharide-induced neurotoxicity in Sprague-Dawley rats
Dosage:30-120 mg/kg for 14 days
Administration:Intraperitoneal injection
Result:Reduced LPS-induced cognitive impairment and imflammatory cytokine, promoted Nrf2 pathway at concentration of 120 mg/kg.
体外研究：
Madecassosid (30，100 μM，12 h) 增强了氧化应激损伤的 HUVECs 细胞的细胞活力。Madecassosid (10-100 μM，12 h) 抑制 p38 MAPK 的磷酸化和 Caspase-3 的活性，从而表达出抗凋亡活性。Madecassosid (10-100 μg/L) 对于黑色素细胞的树突收缩展现出抗氧化活性，并且能够维持线粒体膜电位和 Ca2+ 稳态。Madecassosid (30 μM) 通过增加 p-IRS1，Akt 和 p-Akt 在糖毒条件下的表达，提高了胰岛素的分泌。Madecassosid (10 μM，24 h) 通过 III-PI3K/Beclin-1/Bcl-2 通路，抑制Aβ25–35 诱导的神经细胞炎症和自噬反应。
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