产品
编 号：F329446
分子式：C18H32O2
分子量：280.45
分子式：C18H32O2
分子量：280.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 34450-18-5
产品详情
生物活性：
17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC50<100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes. 17-ODYA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
将 17-ODYA (16.5 nmol/min) 直接输注到大鼠的肾皮质间质中会产生利尿和尿钠排泄，这与肾乳头血流增加有关，而肾血流、皮质血流或肾小球滤过率。 17-ODYA (0.28 mg/kg；冠状动脉内；输注 2 至 3 分钟；狗) 在缺血再灌注过程中显著抑制 20-HETE 的产生并产生显著减少心肌梗塞面积。
17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC50<100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes. 17-ODYA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
将 17-ODYA (16.5 nmol/min) 直接输注到大鼠的肾皮质间质中会产生利尿和尿钠排泄，这与肾乳头血流增加有关，而肾血流、皮质血流或肾小球滤过率。 17-ODYA (0.28 mg/kg；冠状动脉内；输注 2 至 3 分钟；狗) 在缺血再灌注过程中显著抑制 20-HETE 的产生并产生显著减少心肌梗塞面积。
产品资料
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