产品
编 号:F329372
分子式:C14H16Cl2N4O3
分子量:359.21
产品类型
结构图
CAS No: 34433-31-3
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产品详情
生物活性:
Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system.
体内研究:
Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1?mg/kg. A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant.Animal Model:Balb/c mice
Dosage:2% and 0.2% of median lethal dose 15.6 and 1.56mg/kg
Administration:Intramuscular injection into the rear limb
Result:Improved vaccination efficacy at the level of immunity regulation by the nervous system.