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编 号：F329090
分子式：C13H21NO3
分子量：239.31
分子式：C13H21NO3
分子量：239.31
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CAS No: 34391-04-3
产品详情
生物活性：
Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting?β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD.
体内研究：
Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice,demonstrated a decrease in eosinophilia and IgE.Animal Model:C57BL/6 female mice?with a pulmonary allergic model
Dosage:1 mg/kg
Administration:Subcutaneous injection; 1 mg/kg; 14 days
Result:Decreased pulmonary inflammation after OVA sensitization.
体外研究：
Levalbuterol (10 μM; 24 hours) induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2expression inairway epithelial cells.Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line.
Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting?β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD.
体内研究：
Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice,demonstrated a decrease in eosinophilia and IgE.Animal Model:C57BL/6 female mice?with a pulmonary allergic model
Dosage:1 mg/kg
Administration:Subcutaneous injection; 1 mg/kg; 14 days
Result:Decreased pulmonary inflammation after OVA sensitization.
体外研究：
Levalbuterol (10 μM; 24 hours) induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2expression inairway epithelial cells.Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line.
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