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编 号：F328978
分子式：C18H23NO3
分子量：301.38
分子式：C18H23NO3
分子量：301.38
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CAS No: 34368-04-2
产品详情
生物活性：
Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion.
体内研究：
Dobutamine has a rapid onset of action and a short half-life .Dobutamine (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice.Dobutamine results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice.Low doses of Dobutamine significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice.Dobutamine increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost.Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.Animal Model:Tgαq*44 mice (heart failure models)
Dosage:0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose
Administration:Intraperitoneal injection
Result:Induced different response in cardiac function on a low and high dose in mice with with heart failure.
Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion.
体内研究：
Dobutamine has a rapid onset of action and a short half-life .Dobutamine (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice.Dobutamine results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice.Low doses of Dobutamine significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice.Dobutamine increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost.Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.Animal Model:Tgαq*44 mice (heart failure models)
Dosage:0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose
Administration:Intraperitoneal injection
Result:Induced different response in cardiac function on a low and high dose in mice with with heart failure.
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