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编 号：F327951
分子式：C4H8S3
分子量：152.3
分子式：C4H8S3
分子量：152.3
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CAS No: 34135-85-8
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生物活性：
Allyl methyl trisulfide is a volatile organic compound and a component of garlic (Allium sativum L.) essential oil, which has antibacterial, antioxidant and antitumor activities.
体内研究：
Allyl methyl trisulfide(AMS)(50-200 mg/kg, orally, daily, 30 days)在 STZ 诱导的高血糖大鼠中具有保护功效。可以导致血糖和促炎标志物 TNF-α、IL-6、NF-κB p65 表达显著降低，而血浆胰岛素水平升高，并且具有一定的抗氧化活性。Animal Model:Male Wistar rats (170-190 g)
Dosage:50, 100 and 200 mg/kg
Administration:orally in the daily morning for 30 days
Result:Enhanced body, organ weight and reduced food, water intake.Dose-dependently decreased plasma glucose and enhanced insulin.Attenuated the oxidative stress stimulated by STZ in hepatocytes.Increased activity of hepatotoxicity markers AST, ALT and ALP.Significantly downregulated the expression of pro-inflammatory proteins, cytokines (TNF-α and IL-6) and transcription factors (NF-κB p65).
Allyl methyl trisulfide is a volatile organic compound and a component of garlic (Allium sativum L.) essential oil, which has antibacterial, antioxidant and antitumor activities.
体内研究：
Allyl methyl trisulfide(AMS)(50-200 mg/kg, orally, daily, 30 days)在 STZ 诱导的高血糖大鼠中具有保护功效。可以导致血糖和促炎标志物 TNF-α、IL-6、NF-κB p65 表达显著降低，而血浆胰岛素水平升高，并且具有一定的抗氧化活性。Animal Model:Male Wistar rats (170-190 g)
Dosage:50, 100 and 200 mg/kg
Administration:orally in the daily morning for 30 days
Result:Enhanced body, organ weight and reduced food, water intake.Dose-dependently decreased plasma glucose and enhanced insulin.Attenuated the oxidative stress stimulated by STZ in hepatocytes.Increased activity of hepatotoxicity markers AST, ALT and ALP.Significantly downregulated the expression of pro-inflammatory proteins, cytokines (TNF-α and IL-6) and transcription factors (NF-κB p65).
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