产品
编 号：F004242
分子式：C14H12O4
分子量：244.24
分子式：C14H12O4
分子量：244.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
165
In-stock
5mg
330
In-stock
10mg
528
In-stock
25mg
896
In-stock
50mg
1256
In-stock
100mg
1784
In-stock
结构图
CAS No: 10083-24-6
产品详情
生物活性：
Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI). Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties. Piceatannol induces apoptosis in DLBCL cell lines. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells.
体内研究：
Piceatannol (10, 20, and 40 mg/kg) inhibits the pulmonary edema and? reduces the infiltration of inflammatory cells induced by lipopolysaccharide. Piceatannol (10, 20, and 40 mg/kg) alleviates the myeloperoxidase activity and? inhibits the production of iNOS and COX-2 expressions in lung tissuesinduced by lipopolysaccharide. Piceatannol (10, 20, and 40 mg/kg; intraperitoneally 1 h) treatment alleviates inflammatory response by inhibiting the activation of TLR/NF-κB signaling pathway in lung tissues during acute lung injury (ALI) induced by LPS.Animal Model:Male C57BL/6 mice (40-50 g)
Dosage:10, 20, and 40 mg/kg
Administration:Intraperitoneally 1 h before LPS challenge
Result:Significantly reduced the pulmonary edema induced by LPS.
体外研究：
Piceatannol is a resveratrol metabolite.SYK inhibitor Piceatannol (3.125, 6.25, 12.5, 25, and 50 μM; 72 hours) inhibits cell growth of six diffuse large B cell lymphomas (DLBCL) cell lines (SUDHL-6, U2392,DOHH2,Karpas 422, VAL, OCI Ly19) with IC50s of 18 μM, 25 μM, 37 μM, 48 μM, >50 μM and >50 μM, respectively.
Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI). Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties. Piceatannol induces apoptosis in DLBCL cell lines. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells.
体内研究：
Piceatannol (10, 20, and 40 mg/kg) inhibits the pulmonary edema and? reduces the infiltration of inflammatory cells induced by lipopolysaccharide. Piceatannol (10, 20, and 40 mg/kg) alleviates the myeloperoxidase activity and? inhibits the production of iNOS and COX-2 expressions in lung tissuesinduced by lipopolysaccharide. Piceatannol (10, 20, and 40 mg/kg; intraperitoneally 1 h) treatment alleviates inflammatory response by inhibiting the activation of TLR/NF-κB signaling pathway in lung tissues during acute lung injury (ALI) induced by LPS.Animal Model:Male C57BL/6 mice (40-50 g)
Dosage:10, 20, and 40 mg/kg
Administration:Intraperitoneally 1 h before LPS challenge
Result:Significantly reduced the pulmonary edema induced by LPS.
体外研究：
Piceatannol is a resveratrol metabolite.SYK inhibitor Piceatannol (3.125, 6.25, 12.5, 25, and 50 μM; 72 hours) inhibits cell growth of six diffuse large B cell lymphomas (DLBCL) cell lines (SUDHL-6, U2392,DOHH2,Karpas 422, VAL, OCI Ly19) with IC50s of 18 μM, 25 μM, 37 μM, 48 μM, >50 μM and >50 μM, respectively.
产品资料
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