产品
编 号:F327653
分子式:C15H9BrN2O3S
分子量:377.21
产品类型
结构图
CAS No: 340316-62-3
联系客服
产品详情
生物活性:
SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton.
体外研究:
SMIFH2 (25 uM; 1-16 hours) induces dynamic cytoskeletal remodelling in U2OS cells. SMIFH2 (25 μM) reduces p300, mDia2 and p53 levels in a proteasome-independent manner.SMIFH2 reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism that influences remodelling of the cytoskeleton.