产品
编 号：F327533
分子式：C22H32N4O4
分子量：416.51
分子式：C22H32N4O4
分子量：416.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 340021-17-2
产品详情
生物活性：
Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure.
体内研究：
Tonapofylline (BG 9928) (1 mg/kg；po，bid，第 0-6 天) 持续降低 NSC 119875 后血清肌酐和血尿素氮水平，改善体重恢复并显著减弱 NSC 119875 诱导的 (5.5 mg/kg) 肾脏病理评分。Animal Model:Female viral antigen-free Sprague-Dawley rats
Dosage:1 mg/kg
Administration:Oral administration; twice a day, days 0-6
Result:Produced sustained reductions in post-NSC 119875 serum creatinine and blood urea nitrogen levels, improved body weight recovery and significant attenuation of NSC 119875-induced (5.5 mg/kg) kidney pathology scores.
Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure.
体内研究：
Tonapofylline (BG 9928) (1 mg/kg；po，bid，第 0-6 天) 持续降低 NSC 119875 后血清肌酐和血尿素氮水平，改善体重恢复并显著减弱 NSC 119875 诱导的 (5.5 mg/kg) 肾脏病理评分。Animal Model:Female viral antigen-free Sprague-Dawley rats
Dosage:1 mg/kg
Administration:Oral administration; twice a day, days 0-6
Result:Produced sustained reductions in post-NSC 119875 serum creatinine and blood urea nitrogen levels, improved body weight recovery and significant attenuation of NSC 119875-induced (5.5 mg/kg) kidney pathology scores.
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