产品
编 号:F037999
分子式:C26H34O7
分子量:458.54
产品类型
结构图
CAS No: 1108-68-5
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产品详情
生物活性:
Cinobufotalin is a cardiotonic steroids or bufadienolides, is extracted from the skin secretions of the giant toads. Cinobufotalin has been used as a cardiotonic, diuretic and a hemostatic agent, Cinobufotalin is also a potential anti-lung cancer agent.
体内研究:
Cinobufotalin (1-5 mg/kg;腹腔注射;每天两次;持续 1 周;雄性裸鼠) 处理可抑制体内 A549 肺癌细胞生长。Animal Model:Male nude mice (4-6 weeks old, BALB/c) with A549 cells
Dosage:1 mg/kg or 5 mg/kg
Administration:Intraperitoneal injection; twice daily; for 1 weeks
Result:Inhibited A549 lung cancer cell growth in vivo.
体外研究:
Cinobufotalin (0.1-10 μM;72 小时;A549、H460 和 HTB-58 人肺癌细胞) 处理可诱导针对肺癌细胞的细胞毒性作用。