产品
编 号：F325242
分子式：C18H19ClN4
分子量：326.82
分子式：C18H19ClN4
分子量：326.82
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 337972-47-1
产品详情
生物活性：
FAUC 213 is an orally active and highly selective dopamine D4 receptor complete antagonist with a Ki of 2.2 nM for hD4.4. FAUC 213 has less activity on D2 and D3 receptors (Kis of 3.4 μM, 5.3 μM for hD2, hD3, respectively). FAUC 213 can cross the blood-brain barrier (BBB). FAUC 213 exhibits atypical antipsychotic characteristic.
体内研究：
FAUC 213 (7.5-30 mg/kg; orally; single dose) significantly reduces this elevation in AMPH-induced locomotor hyper-activity only pre-treatment with 30 mg/kg. FAUC 213 significantly restores the prepulse inhibition (PPI) reduction caused by the apomorphine (APO) treatment with 30 mg/kg. Animal Model:Male adult Wistar rats weighing 300-350 g
Dosage:7.5, 15, 30 mg/kg
Administration:Orally; single dose
Result:Significantly reduced this elevation in amphetamin (AMPH)-induced locomotor hyper-activity only pre-treatment with 30 mg/kg.
体外研究：
FAUC 213 inhibits p5-HT1 (Ki=1.2 μM)，p5-HT2 (Ki=0.52 μM)，pα1 (Ki=0.27 μM).
FAUC 213 is an orally active and highly selective dopamine D4 receptor complete antagonist with a Ki of 2.2 nM for hD4.4. FAUC 213 has less activity on D2 and D3 receptors (Kis of 3.4 μM, 5.3 μM for hD2, hD3, respectively). FAUC 213 can cross the blood-brain barrier (BBB). FAUC 213 exhibits atypical antipsychotic characteristic.
体内研究：
FAUC 213 (7.5-30 mg/kg; orally; single dose) significantly reduces this elevation in AMPH-induced locomotor hyper-activity only pre-treatment with 30 mg/kg. FAUC 213 significantly restores the prepulse inhibition (PPI) reduction caused by the apomorphine (APO) treatment with 30 mg/kg. Animal Model:Male adult Wistar rats weighing 300-350 g
Dosage:7.5, 15, 30 mg/kg
Administration:Orally; single dose
Result:Significantly reduced this elevation in amphetamin (AMPH)-induced locomotor hyper-activity only pre-treatment with 30 mg/kg.
体外研究：
FAUC 213 inhibits p5-HT1 (Ki=1.2 μM)，p5-HT2 (Ki=0.52 μM)，pα1 (Ki=0.27 μM).
产品资料
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