产品
编 号：F324301
分子式：C42H58O6
分子量：658.91
分子式：C42H58O6
分子量：658.91
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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2mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 3351-86-8
产品详情
生物活性：
Fucoxanthin (all-trans-Fucoxanthin) is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities.
体内研究：
Fucoxanthin (10-2000 mg/kg, p.o.) 不会导致 ICR 小鼠和大鼠的死亡和外观异常。Fucoxanthin (10-50 mg/kg/day, p.o.) 通过提高小鼠抗氧化能力对镉引起的肾损伤小鼠模型起到保护作用。Fucoxanthin (0.1-10 mg/kg, i.v.) 对 EIU (endotoxin-induced uveitis) 显示出剂量依赖性的抗眼部炎症作用。Animal Model:6-week-old male and female Crl:CD (SD) rats, 6-week-old male and female ICR mice
Dosage:10-2000 mg/kg/day for 28/30 days
Administration:p.o.
Result:No abnormal appearance or death occurred in the rats and ICR mice.Significantly increased the concentration of serum total cholesterol in rats and ICR mice.
Animal Model:mice models subjected to cadmium-induced kidney damage, Six- to eight-week-old male Kunming mice (weight, 22–26 gram (g)/per mouse)
Dosage:10-50 mg/kg/day for 14 days
Administration:p.o.
Result:Blocked the Cd-induced increase in the cadmium level.Significantly decreased the levels of blood urea nitrogen, creatinine and lipid peroxidation, and increased the levels of SOD, POD and reduced glutathione.Helped to restore mitochondrial structure and inhibit renal cell apoptosis.
体外研究：
Fucoxanthin (2.8-6.2 μM, 24 h) 对所有测试的 Mtb 菌株均表现出明显的抑菌作用，MIC 为 2.8-4.1 μM。Fucoxanthin (0-25 μM, 24 h) 抑制 HeLa 和 SiHa 宫颈癌细胞系增殖，并促使细胞停滞在 G0/G1 细胞周期阶段。Fucoxanthin (10 μM, 12 h) 通过诱导 G1 细胞周期停滞和凋亡来抑制 HTLV-1 感染的 T 细胞系的细胞活力，从而表现抗癌活性。Fucoxanthin (0-100 μg/mL, 24 h) 以剂量依赖性方式抑制 RAW 264.7 细胞中 TNF-α，PGE2，iNOS 和 COX-2 蛋白的表达。
Fucoxanthin (all-trans-Fucoxanthin) is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities.
体内研究：
Fucoxanthin (10-2000 mg/kg, p.o.) 不会导致 ICR 小鼠和大鼠的死亡和外观异常。Fucoxanthin (10-50 mg/kg/day, p.o.) 通过提高小鼠抗氧化能力对镉引起的肾损伤小鼠模型起到保护作用。Fucoxanthin (0.1-10 mg/kg, i.v.) 对 EIU (endotoxin-induced uveitis) 显示出剂量依赖性的抗眼部炎症作用。Animal Model:6-week-old male and female Crl:CD (SD) rats, 6-week-old male and female ICR mice
Dosage:10-2000 mg/kg/day for 28/30 days
Administration:p.o.
Result:No abnormal appearance or death occurred in the rats and ICR mice.Significantly increased the concentration of serum total cholesterol in rats and ICR mice.
Animal Model:mice models subjected to cadmium-induced kidney damage, Six- to eight-week-old male Kunming mice (weight, 22–26 gram (g)/per mouse)
Dosage:10-50 mg/kg/day for 14 days
Administration:p.o.
Result:Blocked the Cd-induced increase in the cadmium level.Significantly decreased the levels of blood urea nitrogen, creatinine and lipid peroxidation, and increased the levels of SOD, POD and reduced glutathione.Helped to restore mitochondrial structure and inhibit renal cell apoptosis.
体外研究：
Fucoxanthin (2.8-6.2 μM, 24 h) 对所有测试的 Mtb 菌株均表现出明显的抑菌作用，MIC 为 2.8-4.1 μM。Fucoxanthin (0-25 μM, 24 h) 抑制 HeLa 和 SiHa 宫颈癌细胞系增殖，并促使细胞停滞在 G0/G1 细胞周期阶段。Fucoxanthin (10 μM, 12 h) 通过诱导 G1 细胞周期停滞和凋亡来抑制 HTLV-1 感染的 T 细胞系的细胞活力，从而表现抗癌活性。Fucoxanthin (0-100 μg/mL, 24 h) 以剂量依赖性方式抑制 RAW 264.7 细胞中 TNF-α，PGE2，iNOS 和 COX-2 蛋白的表达。
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