产品
编 号：F323896
分子式：C11H16N2O2
分子量：208.26
分子式：C11H16N2O2
分子量：208.26
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CAS No: 33419-68-0
产品详情
生物活性：
Safrazine is an irreversible, non-specific and orally active monoamine oxidase (MAO) inhibitor. Safrazine can be used for the research of depression.
体内研究：
Safrazine (oral; 3, 10, 30 mg/kg) causes the increases contents of monoamine lasted for at least 24 h.Safrazine strongly inhibits both 5-HT and PEA deaminations, but shows no selectivity toward the substrate used.Animal Model:Male ddY mice
Dosage:3, 10, 30 mg/kg
Administration:Oral
Result:Inhibited significantly both 5-HT and PEA deaminations at only 3 mg/kg by 77% and 71%, respectively.Completely reduced both deaminations at 10 and 30 mg/kg and not observed specificity toward substrates.
体外研究：
Safrazine (0.1-0.5 μM; 0-80 min) strengthenes the inhibitory potency by preincubation in a time-dependent manner.
Safrazine is an irreversible, non-specific and orally active monoamine oxidase (MAO) inhibitor. Safrazine can be used for the research of depression.
体内研究：
Safrazine (oral; 3, 10, 30 mg/kg) causes the increases contents of monoamine lasted for at least 24 h.Safrazine strongly inhibits both 5-HT and PEA deaminations, but shows no selectivity toward the substrate used.Animal Model:Male ddY mice
Dosage:3, 10, 30 mg/kg
Administration:Oral
Result:Inhibited significantly both 5-HT and PEA deaminations at only 3 mg/kg by 77% and 71%, respectively.Completely reduced both deaminations at 10 and 30 mg/kg and not observed specificity toward substrates.
体外研究：
Safrazine (0.1-0.5 μM; 0-80 min) strengthenes the inhibitory potency by preincubation in a time-dependent manner.
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