产品
编 号：F322396
分子式：C13H14BrN3O
分子量：308.17
分子式：C13H14BrN3O
分子量：308.17
产品类型
规格
价格
是否有货
5mg
询价
In-stock
10mg
询价
In-stock
25mg
询价
In-stock
50mg
询价
In-stock
100mg
询价
In-stock
结构图
CAS No: 330981-72-1
产品详情
生物活性：
AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes.
体内研究：
AS1269574 sgnificantly reduced the blood glucose AUC after 2 h (AUC0-2h) of administration.Animal Model:Eight-week-old ICR mice
Dosage:100 mg/kg
Administration:P.o.
Result:Sgnificantly reduced the blood glucose AUC after 2 h (AUC0-2h) of administration. Similarly, plasma insulin AUC0-2h was significantly higher in the mice.
AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes.
体内研究：
AS1269574 sgnificantly reduced the blood glucose AUC after 2 h (AUC0-2h) of administration.Animal Model:Eight-week-old ICR mice
Dosage:100 mg/kg
Administration:P.o.
Result:Sgnificantly reduced the blood glucose AUC after 2 h (AUC0-2h) of administration. Similarly, plasma insulin AUC0-2h was significantly higher in the mice.
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