产品
编 号：F037713
分子式：C19H12F3N3O3S
分子量：419.38
分子式：C19H12F3N3O3S
分子量：419.38
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规格
价格
是否有货
1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 110703-94-1
产品详情
生物活性：
Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications.
体内研究：
Zopolrestat (2.5 mg/kg-50 mg/kg；口服；每天一次，持续 5 天，然后恢复 7 天) 可防止山梨糖醇在糖尿病大鼠肾皮质中积聚，并使半乳糖血症大鼠升高的肾血流量正常化。Animal Model:Male Sprague-Dawley rats (made diabetic by iv injection of streptozotocin).
Dosage:2.5 mg/kg-50 mg/kg
Administration:P.o.; once-a-day for 5 days
Result:Its ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively.
体外研究：
Zopolrestat 是人和大鼠酶减少甘油醛和葡萄糖的有效抑制剂。
Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications.
体内研究：
Zopolrestat (2.5 mg/kg-50 mg/kg；口服；每天一次，持续 5 天，然后恢复 7 天) 可防止山梨糖醇在糖尿病大鼠肾皮质中积聚，并使半乳糖血症大鼠升高的肾血流量正常化。Animal Model:Male Sprague-Dawley rats (made diabetic by iv injection of streptozotocin).
Dosage:2.5 mg/kg-50 mg/kg
Administration:P.o.; once-a-day for 5 days
Result:Its ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively.
体外研究：
Zopolrestat 是人和大鼠酶减少甘油醛和葡萄糖的有效抑制剂。
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