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编 号：F322226
分子式：C187H320N56O50
分子量：4152.96
分子式：C187H320N56O50
分子量：4152.96
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CAS No: 330648-32-3
产品详情
生物活性：
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with Ki values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca2+/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow.
体内研究：
Urocortin II, mouse (1-10 μg; icv and i.v.; 成年雄性 SD 大鼠) 诱导 Fos 的表达。Urocortin II, mouse (1 μg; icv; 成年雄性 SD 大鼠) 参与中枢自主神经系统和食欲控制。Animal Model:Adult male Sprague-Dawley rats (250-300 g)
Dosage:1, 5, and 10 μg
Administration:Intracerebroventrical injection and intravenous injection; 1, 5, or 10 μg per animal in 2 μL of saline for i.c.v. injections or 200 μL for i.v. administration
Result:Induced Fos expression in a dose-dependent manner.
Animal Model:Adult male Sprague-Dawley rats (250-300 g)
Dosage:1 μg
Administration:Intracerebroventrical injection
Result:Reduced food intake over the 12-h interval.
体外研究：
Urocortin II, mouse 通过激活 CRF2 受体在小鼠心室肌细胞中引起正性肌力和正性变性作用。Urocortin II, mouse 通过以 cAMP/PKA 和 Ca2+/CaMKII 依赖性方式激活 CRF2 受体。
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with Ki values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca2+/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow.
体内研究：
Urocortin II, mouse (1-10 μg; icv and i.v.; 成年雄性 SD 大鼠) 诱导 Fos 的表达。Urocortin II, mouse (1 μg; icv; 成年雄性 SD 大鼠) 参与中枢自主神经系统和食欲控制。Animal Model:Adult male Sprague-Dawley rats (250-300 g)
Dosage:1, 5, and 10 μg
Administration:Intracerebroventrical injection and intravenous injection; 1, 5, or 10 μg per animal in 2 μL of saline for i.c.v. injections or 200 μL for i.v. administration
Result:Induced Fos expression in a dose-dependent manner.
Animal Model:Adult male Sprague-Dawley rats (250-300 g)
Dosage:1 μg
Administration:Intracerebroventrical injection
Result:Reduced food intake over the 12-h interval.
体外研究：
Urocortin II, mouse 通过激活 CRF2 受体在小鼠心室肌细胞中引起正性肌力和正性变性作用。Urocortin II, mouse 通过以 cAMP/PKA 和 Ca2+/CaMKII 依赖性方式激活 CRF2 受体。
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