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编 号:F322013
分子式:C19H21N3O3S
分子量:371.45
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
SU6656 is a Src family kinases inhibitor with IC50s of 280, 20, 130, 170 nM for Src, Yes, Lyn, and Fyn, respectively. SU6656 inhibits FAK phosphorylation at Y576/577, Y925, Y861 sites. SU6656 also inhibits p-AKT.

体内研究:
SU6656 (2-4 mg/kg;腹腔注射;一次) 显著减少缺血后适应 (IPoCo) 介导的跌倒时间增加。Animal Model:Swiss albino male mice
Dosage:2, 4 mg/kg
Administration:Intraperitoneal injection; once
Result:Significantly decreased IPoCo mediated increase in fall down time.

体外研究:
SU6656 降低 HNSCC 细胞中 Src 家族激酶 (SFK) 的磷酸化。
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