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编 号:F321358
分子式:C16H12O6
分子量:300.26
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生物活性:
Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis.

体内研究:
Cajanin (10 mg/kg, p.o.; daily for 30 consecutive days) increases the BMD levelsin all anatomical regions of the skeleton studied in Sprague Dawley rats.

体外研究:
Cajanin shows strong mitogenic as well as differentiation-promoting effects on osteoblasts.Cajanin induces the phosphorylation of both Erk1/2 and Akt.
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