产品
编 号:F321260
分子式:C19H15Br2N3O3
分子量:493.15
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10mM*1mL in DMSO
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2mg
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
GlyH-101 is a potent CFTR inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current.

体内研究:
GlyH-101 (2.5 μg) reduces by about 80% cholera toxin-induced intestinal fluid secretion in mouse.

体外研究:
GlyH-101 (0-50 μM) shows antiproliferative activity in PCT and PS120 cells.GlyH-101 (0.5, 1, 5, 10 μM) inhibits CFTR-like current in a concentration-dependent manner in PCT cells.GlyH-101 (0.5, 1, 5, 10 μM) inhibits the VSORC current with IC50s of 5.38, 6.26 μM for PS120, PCT cells, respectively.
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