产品
编 号：F320558
分子式：C17H21N7O4
分子量：387.39
分子式：C17H21N7O4
分子量：387.39
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
400
In-stock
5mg
320
In-stock
10mg
560
In-stock
50mg
2000
In-stock
100mg
3200
In-stock
250mg
询价
In-stock
结构图
CAS No: 326914-06-1
产品详情
生物活性：
MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR. MHY1485 inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.
体内研究：
MHY1485 (intraperitoneal injection; 10?mg/kg, 2 days) blocks the autophagy signaling induced by follicle-stimulating hormone (FSH).It increases p-mTOR and p-S6K1 expression levels,whereas LC3 expression shows no marked change compared to that in the control group.Animal Model:4-week-old female ICR mice
Dosage:10?mg/kg, 2 days
Administration:Intraperitoneal injection
Result:Suppressed the autophagy level following FSH treatment.?
体外研究：
MHY1485 (10 μM; 4 hours) shows that GCDC-induced autophagic activity is inhibited by upregulating p-mTOR expression and downregulating LC3 and p62 expression in HCC cells.MHY1485 (5 μM; 6 hours) increases the LC3II/LC3I ratio in a dose and time-dependently manner due to presumably inhibited LC3II degradation in rat liver Ac2F cells.MHY1485 (0.5-2 μM; 6 hours) increases the phosphorylation of mTOR at ser2448 and upregulates the level of phosphorylation of 4E-BP1 in a dose-dependently manner inAc2F cells.
MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR. MHY1485 inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.
体内研究：
MHY1485 (intraperitoneal injection; 10?mg/kg, 2 days) blocks the autophagy signaling induced by follicle-stimulating hormone (FSH).It increases p-mTOR and p-S6K1 expression levels,whereas LC3 expression shows no marked change compared to that in the control group.Animal Model:4-week-old female ICR mice
Dosage:10?mg/kg, 2 days
Administration:Intraperitoneal injection
Result:Suppressed the autophagy level following FSH treatment.?
体外研究：
MHY1485 (10 μM; 4 hours) shows that GCDC-induced autophagic activity is inhibited by upregulating p-mTOR expression and downregulating LC3 and p62 expression in HCC cells.MHY1485 (5 μM; 6 hours) increases the LC3II/LC3I ratio in a dose and time-dependently manner due to presumably inhibited LC3II degradation in rat liver Ac2F cells.MHY1485 (0.5-2 μM; 6 hours) increases the phosphorylation of mTOR at ser2448 and upregulates the level of phosphorylation of 4E-BP1 in a dose-dependently manner inAc2F cells.
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