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编 号:F320181
分子式:C50H63N9O10
分子量:950.09
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生物活性:
Linopristin is a kind of type B streptogramin antibiotics. Linopristin, together with type A, Flopristin, to form the streptogramin combination NXL 103. Linopristin exhibit synergistic antimicrobial activity against certain pathogenic bacteria with Flopristin. The preference ratio of Linopristin/Flopristin is 30:70 (w/w) or 70 μM Linopristin +120 μM Flopristin.

体外研究:
Linopristin (0-64 μg/mL) 对革兰氏阴性病原菌的抑菌作用不大,原因是其外细胞膜渗透性差。Linopristin 抑制粪肠球菌、金黄色葡萄球菌和肺炎葡萄球菌的生长,IC50 分别为 8 μg/mL、32 μg/mL 和 4 μg/mL。
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