产品
编 号：F319703
分子式：C31H30ClN5O7
分子量：620.05
分子式：C31H30ClN5O7
分子量：620.05
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CAS No: 324572-93-2
产品详情
生物活性：
T-0156 is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM). T-0156 inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 enhances the nitric oxide (NO)/cGMP pathway.
体外研究：
T-0156 at 10 and 100 nM increases cGMP levels, causing relaxation of the tissue in the isolated rabbit corpus cavernosum.
T-0156 is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM). T-0156 inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 enhances the nitric oxide (NO)/cGMP pathway.
体外研究：
T-0156 at 10 and 100 nM increases cGMP levels, causing relaxation of the tissue in the isolated rabbit corpus cavernosum.
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