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编 号:F037485
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CAS No: 11056-06-7
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Bleomycin is a glycopeptide antibiotic. Bleomycin has potent antitumour activities against a range of lymphomas, head and neck cancers and germ-cell tumours. Bleomycin can be used for the research of cancer and chemotherapy.
体内研究:
Bleomycin (1 mg and 10 μg; retro-orbitary sinus injection once) affects cells in mitosis, induces apoptosis in tumor models.Animal Model:C57Bl/6 mice with LPB and B16F0 tumours
Dosage:1 mg and 10 μg
Administration:Retro-orbitary sinus injection; 1 mg and 10 μg once
Result:Decreased in the fraction of cells in mitosis in both tumours, induced cell apoptosis after the electric pulses delivery, inceased the amount of atypical cells in LPB tumours.
体外研究:
Bleomycin (0-4 mU/mL; 1 h) induces double-strand break in V79 cells.Bleomycin (0-1 mU/mL; 1 h) reduces migration of DNA from S-phase cells.Bleomycin (0-3 μg/mL; 1 h) induces chromatid aberrations in G2 cells.