产品
编 号:F317072
分子式:C22H30N4O2S2
分子量:446.63
产品类型
结构图
CAS No: 316-81-4
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生物活性:
Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder.
体内研究:
Thioproperazine (5 mg/kg; i.p.; single) increases accumulation of dopamine in rat striatum.Animal Model:Male charles river rats (200-250 g).
Dosage:5 mg/kg
Administration:Intraperitoneal injection; single.
Result:Markedly decreased dopamine levels (26%), and accelerated synthesis and utilization of dopamine in the striatum (dopamine specific activity was enhanced 250%).