产品
编 号：F316999
分子式：C9H11FN2O6
分子量：262.19
分子式：C9H11FN2O6
分子量：262.19
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
258
In-stock
100mg
400
In-stock
结构图
CAS No: 316-46-1
产品详情
生物活性：
5-Fluorouridine, a metabolite of 5-fluorouracil (HY-90006), is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis.
体内研究：
5-Fluorouridine (567-1500 mg/kg; i.p.; daily, for 20 d) induce gastrointestinal toxicity in the mice.Animal Model:Male CBA/J mice (17-20 g; 6-8 weeks of age)
Dosage:Intraperitoneal injection; daily, 20 days
Administration:567, 700, 900, 1100, 1300, and 1500 mg/kg
Result:567, 700, 900, 1100, 1300, and 1500 mg/kg
体外研究：
5-Fluorouridine (167 μM; 24-96 h) inhibits MKN45 cells and MKN28 cells in a time-dependent manner.?5-Fluorouridine (10 μM; 24 h; HCT-116 cells) induces apoptosis and increases the percentage of apoptotic cells. 5-Fluorouridine upregulates the expression of 33 genes, including a group of genes as growth factors, cytokines and chemokines (e.g. IL-3, IL -4, B-cell growth factor 1 and stem cell growth factor).?5-Fluorouridine (10 μM; 8-24 h; HCT-116 cells) incorporates into both total and poly A RNA.
5-Fluorouridine, a metabolite of 5-fluorouracil (HY-90006), is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis.
体内研究：
5-Fluorouridine (567-1500 mg/kg; i.p.; daily, for 20 d) induce gastrointestinal toxicity in the mice.Animal Model:Male CBA/J mice (17-20 g; 6-8 weeks of age)
Dosage:Intraperitoneal injection; daily, 20 days
Administration:567, 700, 900, 1100, 1300, and 1500 mg/kg
Result:567, 700, 900, 1100, 1300, and 1500 mg/kg
体外研究：
5-Fluorouridine (167 μM; 24-96 h) inhibits MKN45 cells and MKN28 cells in a time-dependent manner.?5-Fluorouridine (10 μM; 24 h; HCT-116 cells) induces apoptosis and increases the percentage of apoptotic cells. 5-Fluorouridine upregulates the expression of 33 genes, including a group of genes as growth factors, cytokines and chemokines (e.g. IL-3, IL -4, B-cell growth factor 1 and stem cell growth factor).?5-Fluorouridine (10 μM; 8-24 h; HCT-116 cells) incorporates into both total and poly A RNA.
产品资料
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