产品
编 号：F316781
分子式：C23H29N3O
分子量：363.5
分子式：C23H29N3O
分子量：363.5
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 315-72-0
产品详情
生物活性：
Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD).
体内研究：
Opipramol (i.p.; 5-50 mg/kg) increases dopamine release in vivo.Animal Model:Sprague-Dawley rats (male, 150-l 80 g)
Dosage:5-50 mg/kg
Administration:Intraperitoneal injections
Result:Increased the levels of DOPAC and HVA in the striatum of the rat, without changing the steady-state levels of DA.Potently increased the metabolism of dopamine in the striatum, olfactory tubercle and pyriform cortex of the rat.Increased plasma prolactin in the rat, only at a dose as large as 50 mg/kg dose.
体外研究：
Opipramol can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol inhibit the uptake of [3H] DA in crude synaptosomal preparations with an IC50 value of 5.5 μM.
Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD).
体内研究：
Opipramol (i.p.; 5-50 mg/kg) increases dopamine release in vivo.Animal Model:Sprague-Dawley rats (male, 150-l 80 g)
Dosage:5-50 mg/kg
Administration:Intraperitoneal injections
Result:Increased the levels of DOPAC and HVA in the striatum of the rat, without changing the steady-state levels of DA.Potently increased the metabolism of dopamine in the striatum, olfactory tubercle and pyriform cortex of the rat.Increased plasma prolactin in the rat, only at a dose as large as 50 mg/kg dose.
体外研究：
Opipramol can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol inhibit the uptake of [3H] DA in crude synaptosomal preparations with an IC50 value of 5.5 μM.
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