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编 号:F316293
分子式:C10H12N2O8
分子量:288.21
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1mg
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生物活性:
Orotidine, a nucleotide, is an intermediate in pyrimidine nucleotide biosynthesis in RNA and DNA. Orotidine is mainly found in bacteria, fungi and plants.

体外研究:
Extant de novo biosynthetic pathway uses Orotidine 50-monophosphate to synthesize the canonical pyrimidine nucleotides in RNA and DNA. In this context, Orotidine is the only nucleotide that is synthesized through a ‘direct intermolecular nucleosidation’ step, with an attack of the fully-preformed nucleobase (orotic acid) on the activated 5-phosphoribosyl-diphosphate as opposed to the purine nucleotides whose heterocyclic rings are constructed stepwise on the sugar.
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