产品
编 号：F316244
分子式：C16H12FN3O3
分子量：313.28
分子式：C16H12FN3O3
分子量：313.28
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
480
In-stock
500mg
720
In-stock
结构图
CAS No: 31430-15-6
产品详情
生物活性：
Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites.
体内研究：
Flubendazole (10、30mg/kg；腹腔注射；每隔一天；14 天) 可抑制结直肠癌 (CRC) 肿瘤异种移植物的生长。 Animal Model:Female BALB/c athymic nude mice (6-8?weeks) with HCT116 cells
Dosage:10? or 30?mg/kg
Administration:Intraperitoneal injection; every other day; 14 days
Result:Markedly reduced the tumor volume. Significantly reduces the protein level of P-STAT3, promotes autophagy and induces apoptosis in vivo.
体外研究：
Flubendazole (0-400 μM；48小时) 抑制人结直肠癌 (CRC) 细胞增殖。Flubendazole (0.3-1.2 μM；48?小时) 可诱导 CRC 细胞凋亡。Flubendazole (0.3-1.2 μM；24小时) 通过灭活 mTOR 和 P62 并上调 CRC 细胞中的 LC3-I/II 来诱导自噬启动。Flubendazole (0.3-1.2 μM；24小时) 以剂量和时间依赖性方式强烈降低 P-STAT3 的表达。
Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites.
体内研究：
Flubendazole (10、30mg/kg；腹腔注射；每隔一天；14 天) 可抑制结直肠癌 (CRC) 肿瘤异种移植物的生长。 Animal Model:Female BALB/c athymic nude mice (6-8?weeks) with HCT116 cells
Dosage:10? or 30?mg/kg
Administration:Intraperitoneal injection; every other day; 14 days
Result:Markedly reduced the tumor volume. Significantly reduces the protein level of P-STAT3, promotes autophagy and induces apoptosis in vivo.
体外研究：
Flubendazole (0-400 μM；48小时) 抑制人结直肠癌 (CRC) 细胞增殖。Flubendazole (0.3-1.2 μM；48?小时) 可诱导 CRC 细胞凋亡。Flubendazole (0.3-1.2 μM；24小时) 通过灭活 mTOR 和 P62 并上调 CRC 细胞中的 LC3-I/II 来诱导自噬启动。Flubendazole (0.3-1.2 μM；24小时) 以剂量和时间依赖性方式强烈降低 P-STAT3 的表达。
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