产品
编 号：F315477
分子式：C3H7NO3
分子量：105.09
分子式：C3H7NO3
分子量：105.09
产品类型
规格
价格
是否有货
500mg
320
In-stock
1g
400
In-stock
5g
560
In-stock
结构图
CAS No: 312-84-5
产品详情
生物活性：
D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.
体内研究：
(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain.Animal Model:Four week old male C57Bl/6 mice
Dosage:10 g/L
Administration:Oral administration (drinking water supplemented with 10 g/l D-serine); throughout 8 weeks
Result:Showed strongly reduced weight gain during the first week of supplementation with paralleled weight gain to HFD fed mice, but no catch up thereafter.
体外研究：
(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR.
D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.
体内研究：
(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain.Animal Model:Four week old male C57Bl/6 mice
Dosage:10 g/L
Administration:Oral administration (drinking water supplemented with 10 g/l D-serine); throughout 8 weeks
Result:Showed strongly reduced weight gain during the first week of supplementation with paralleled weight gain to HFD fed mice, but no catch up thereafter.
体外研究：
(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR.
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