产品
编 号：F315400
分子式：C23H24O6
分子量：396.43
分子式：C23H24O6
分子量：396.43
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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20mg
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结构图
CAS No: 31271-07-5
产品详情
生物活性：
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes.
体内研究：
Gamma-Mangostin (0.5, 1, 2 mg/kg; 口服; 14 天) 能够显著降低 STZ (HY-13753) (30 mg/kg) 诱导的糖尿病 BALB/C 小鼠模型的空腹血糖、胆固醇、血清谷草转氨酶 (SGOT)、血清谷丙转氨酶 (SGPT)，并改善损伤的肝细胞。Gamma-Mangostin (1, 2, 4 mg/kg; 口服; 14 天) 能够显著降低 STZ (HY-13753) (30 mg/kg) 诱导的糖尿病 BALB/C 小鼠血浆中的血尿素氮 (BUN) 和肌酐，改善肾近端小管细胞受损。Gamma-Mangostin (0.1, 0.2, 0.4 mg; 口服; 4 周)能降低糖尿病 ICR 小鼠的空腹血糖水平和口服葡萄糖耐量试验 (OGTT)。Animal Model:STZ (HY-13753) (30 mg/kg)-induced BALB/C diabetic mouse model
Dosage:0.5 mg/kg, 1 mg/kg, 2 mg/kg
Administration:Oral gavage (p.o.); 14 days
Result:Significantly reduced fasting blood glucose, cholesterol, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamate-pyruvate transaminase (SGPT) in diabetic mice.Improved damaged liver cells, primarily those exhibiting swelling, water accumulation, and cell necrosis.
体外研究：
Gamma-Mangostin (0.5, 2.5, 5 μM; 2 小时) 作为一种胰岛素增敏剂，可以剂量依赖性的减轻高血糖，并且对 SD 大鼠颈外动脉中分离的血管平滑细胞和 FL83B 小鼠肝细胞均无毒性。
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes.
体内研究：
Gamma-Mangostin (0.5, 1, 2 mg/kg; 口服; 14 天) 能够显著降低 STZ (HY-13753) (30 mg/kg) 诱导的糖尿病 BALB/C 小鼠模型的空腹血糖、胆固醇、血清谷草转氨酶 (SGOT)、血清谷丙转氨酶 (SGPT)，并改善损伤的肝细胞。Gamma-Mangostin (1, 2, 4 mg/kg; 口服; 14 天) 能够显著降低 STZ (HY-13753) (30 mg/kg) 诱导的糖尿病 BALB/C 小鼠血浆中的血尿素氮 (BUN) 和肌酐，改善肾近端小管细胞受损。Gamma-Mangostin (0.1, 0.2, 0.4 mg; 口服; 4 周)能降低糖尿病 ICR 小鼠的空腹血糖水平和口服葡萄糖耐量试验 (OGTT)。Animal Model:STZ (HY-13753) (30 mg/kg)-induced BALB/C diabetic mouse model
Dosage:0.5 mg/kg, 1 mg/kg, 2 mg/kg
Administration:Oral gavage (p.o.); 14 days
Result:Significantly reduced fasting blood glucose, cholesterol, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamate-pyruvate transaminase (SGPT) in diabetic mice.Improved damaged liver cells, primarily those exhibiting swelling, water accumulation, and cell necrosis.
体外研究：
Gamma-Mangostin (0.5, 2.5, 5 μM; 2 小时) 作为一种胰岛素增敏剂，可以剂量依赖性的减轻高血糖，并且对 SD 大鼠颈外动脉中分离的血管平滑细胞和 FL83B 小鼠肝细胞均无毒性。
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