产品
编 号：F314621
分子式：C15H15NO5S2
分子量：353.41
分子式：C15H15NO5S2
分子量：353.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 310456-65-6
产品详情
生物活性：
IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth.
体内研究：
IMR-1 (腹腔注射；15mg/kg；持续 28 天) 抑制源自患者的异种移植模型中的 Notch 依赖性肿瘤生长。Animal Model:Nude mouses with adenocarcinoma xenograft
Dosage:15mg/kg
Administration:I.p.; for 28 days
Result:Blocks tumor establishment.
IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth.
体内研究：
IMR-1 (腹腔注射；15mg/kg；持续 28 天) 抑制源自患者的异种移植模型中的 Notch 依赖性肿瘤生长。Animal Model:Nude mouses with adenocarcinoma xenograft
Dosage:15mg/kg
Administration:I.p.; for 28 days
Result:Blocks tumor establishment.
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