产品
编 号：F036630
分子式：C32H45Cl4N5O3
分子量：689.54
分子式：C32H45Cl4N5O3
分子量：689.54
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价格
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结构图
CAS No: 1104080-42-3
产品详情
生物活性：
SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
体内研究：
SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice.Animal Model:Mice with C26 adenocarcinoma-induced cachexia model
Dosage:30 mg/kg
Administration:Oral administration; once daily; 15 days
Result:Significantly reduced the tumor induced weight loss.
体外研究：
SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5.
SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
体内研究：
SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice.Animal Model:Mice with C26 adenocarcinoma-induced cachexia model
Dosage:30 mg/kg
Administration:Oral administration; once daily; 15 days
Result:Significantly reduced the tumor induced weight loss.
体外研究：
SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5.
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