产品
编 号：F314467
分子式：C21H22N2O4S
分子量：398.48
分子式：C21H22N2O4S
分子量：398.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 309928-48-1
产品详情
生物活性：
KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis.
体外研究：
KL001 (0.03-71 μM) 在含有 Bmal1-dLuc 或 Per2-dLuc 的稳定 U2OS 报告细胞系中以剂量依赖性方式引起昼夜节律周期延长和振幅降低。 KL001 (2-8 μM；18 小时) 抑制 Pck1 和 G6pc 基因的胰高血糖素依赖性诱导依赖的方式而不影响它们在小鼠原代肝细胞中的基础表达。
KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis.
体外研究：
KL001 (0.03-71 μM) 在含有 Bmal1-dLuc 或 Per2-dLuc 的稳定 U2OS 报告细胞系中以剂量依赖性方式引起昼夜节律周期延长和振幅降低。 KL001 (2-8 μM；18 小时) 抑制 Pck1 和 G6pc 基因的胰高血糖素依赖性诱导依赖的方式而不影响它们在小鼠原代肝细胞中的基础表达。
产品资料
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