产品
编 号：F036528
分子式：C14H15ClN2OS
分子量：294.8
分子式：C14H15ClN2OS
分子量：294.8
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1103523-24-5
产品详情
生物活性：
AMG7703 is a selective and allosteric agonists of FFA2 (GPR43), the receptor for short-chain fatty acids (SCFAs), acetate, and propionate. AMG7703 can be used to research for in inflammatory and metabolic.
体外研究：
AMG7703 (phenylacetamide 1) (30 μM) shows selectivity on FFA2 (GPR43) over FFA1 (GPR40) and FFA3 (GPR41) with in Chinese hamster ovary cells.AMG7703 (0.041, 0.123, 0.37, 1.11 μM) acts as an FFA2 allosteric agonist, activates Gαi coupled signaling pathway.AMG7703 (1, 3, 10, 30 μM) results in Gαi-dependent inhibition of lipolysis in adipocytes (3T3L1).AMG7703 (0.041, 0.123, 0.37, 1.11 μM) exhibits allosteric activity and inhibits Gαi-coupled cAMP with IC50 values of 0.7 μM (hFFA2) and 0.96 μM (mFFA2), respectively; as for Gαq-coupled aequorin inhibition, with EC50s of 0.45 μM (hFFA2) and 1.27 μM (mFFA2), respectively.AMG7703 (0-1 μM) shows the positive cooperating effect of acetate and stimulates calcium mobilization in a concentration-dependent manner in CHO cell stably expressing hFFA2 and aequorin.
AMG7703 is a selective and allosteric agonists of FFA2 (GPR43), the receptor for short-chain fatty acids (SCFAs), acetate, and propionate. AMG7703 can be used to research for in inflammatory and metabolic.
体外研究：
AMG7703 (phenylacetamide 1) (30 μM) shows selectivity on FFA2 (GPR43) over FFA1 (GPR40) and FFA3 (GPR41) with in Chinese hamster ovary cells.AMG7703 (0.041, 0.123, 0.37, 1.11 μM) acts as an FFA2 allosteric agonist, activates Gαi coupled signaling pathway.AMG7703 (1, 3, 10, 30 μM) results in Gαi-dependent inhibition of lipolysis in adipocytes (3T3L1).AMG7703 (0.041, 0.123, 0.37, 1.11 μM) exhibits allosteric activity and inhibits Gαi-coupled cAMP with IC50 values of 0.7 μM (hFFA2) and 0.96 μM (mFFA2), respectively; as for Gαq-coupled aequorin inhibition, with EC50s of 0.45 μM (hFFA2) and 1.27 μM (mFFA2), respectively.AMG7703 (0-1 μM) shows the positive cooperating effect of acetate and stimulates calcium mobilization in a concentration-dependent manner in CHO cell stably expressing hFFA2 and aequorin.
产品资料
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