产品
编 号：F312808
分子式：C10H12N2O4
分子量：224.21
分子式：C10H12N2O4
分子量：224.21
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
360
In-stock
500mg
760
In-stock
结构图
CAS No: 3056-17-5
产品详情
生物活性：
Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis.
体内研究：
Stavudine (d4T) (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice.Animal Model:Male RjOrl Swiss mice weighing 0.028-0.03 kg
Dosage:500 mg/kg
Administration:Daily liquid; 2 weeks
Result:Reduced fat weight gain by 58%, 5.7 g in the control group and 4.9 g in the d4T treated group.Significantly elevated plasma ALT and LDH levels.Reduced plasma acetoacetic acid and beta-hydroxybutyric acid levels.Reduced liver and muscle mtDNA levels at high dose concentration of 500 mg/kg.
体外研究：
Stavudine (d4T) (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages.?Stavudine (d4T) (50 μM) inhibits the assembly of the NLRP3 inflammasome complex and down-regulates the phagocytosis of Aβ 42 by macrophages.?Stavudine (d4T) (10 μM, 7 or 14 days) significantly induced CEM cells apoptosis, especially after 14 days, and increases hydrogen peroxide levels.
Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis.
体内研究：
Stavudine (d4T) (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice.Animal Model:Male RjOrl Swiss mice weighing 0.028-0.03 kg
Dosage:500 mg/kg
Administration:Daily liquid; 2 weeks
Result:Reduced fat weight gain by 58%, 5.7 g in the control group and 4.9 g in the d4T treated group.Significantly elevated plasma ALT and LDH levels.Reduced plasma acetoacetic acid and beta-hydroxybutyric acid levels.Reduced liver and muscle mtDNA levels at high dose concentration of 500 mg/kg.
体外研究：
Stavudine (d4T) (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages.?Stavudine (d4T) (50 μM) inhibits the assembly of the NLRP3 inflammasome complex and down-regulates the phagocytosis of Aβ 42 by macrophages.?Stavudine (d4T) (10 μM, 7 or 14 days) significantly induced CEM cells apoptosis, especially after 14 days, and increases hydrogen peroxide levels.
产品资料
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