产品
编 号：F309897
分子式：C19H23Cl2N5O2
分子量：424.32
分子式：C19H23Cl2N5O2
分子量：424.32
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
500mg
704
In-stock
结构图
CAS No: 29868-97-1
产品详情
生物活性：
Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells.
体内研究：
Pirenzepine (intraperitoneal injection; 0.3?mg/kg; once) treatment shows beneficial effects in lipopolysaccharide-induced septic shock.Animal Model:Male C57BL/6 mice with experimental endotoxemia
Dosage:0.3?mg/kg
Administration:Intraperitoneal injection; 0.3?mg/kg; once
Result:Improved survival rate of LPS-induced septic shock.Relieved LPS-induced pulmonary and hepatic injury.Reduced the expression of SOCS3 at mRNA level.
体外研究：
Pirenzepine (100-140 μg/mL; 24 h) inhibits PC-3 cell proliferation activity.Pirenzepine (110 μg/mL; 24 h) inhibits prostate and lung cancer cell migration.Pirenzepine (100-130 μg/mL; 0-24 h) inhibits the expression of GLI1 in PC-3 cells.
Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells.
体内研究：
Pirenzepine (intraperitoneal injection; 0.3?mg/kg; once) treatment shows beneficial effects in lipopolysaccharide-induced septic shock.Animal Model:Male C57BL/6 mice with experimental endotoxemia
Dosage:0.3?mg/kg
Administration:Intraperitoneal injection; 0.3?mg/kg; once
Result:Improved survival rate of LPS-induced septic shock.Relieved LPS-induced pulmonary and hepatic injury.Reduced the expression of SOCS3 at mRNA level.
体外研究：
Pirenzepine (100-140 μg/mL; 24 h) inhibits PC-3 cell proliferation activity.Pirenzepine (110 μg/mL; 24 h) inhibits prostate and lung cancer cell migration.Pirenzepine (100-130 μg/mL; 0-24 h) inhibits the expression of GLI1 in PC-3 cells.
产品资料
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