产品
编 号：F309379
分子式：C14H12O4
分子量：244.24
分子式：C14H12O4
分子量：244.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
240
In-stock
100mg
320
In-stock
500mg
1120
In-stock
1g
1760
In-stock
结构图
CAS No: 29700-22-9
产品详情
生物活性：
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects.
体内研究：
Oxyresveratrol (2-30 mg/kg; intraperitoneal injection; twice) treatment reduces the brain infarct volume in MCAO rats. Oxyresveratrol treatment diminishes cytochrome c release and decreased caspase-3 activation, and reduces the number of apoptotic nuclei in ischemic brain in MCAO rats.Animal Model:Adult male Wistar rats (300-350 g) with middle cerebral artery occlusion (MCAO)
Dosage:2 mg/kg, 10 mg/kg, 20 mg/kg and 30 mg/kg
Administration:Intraperitoneal injection; twice (at the time of occlusion and at the time of reperfusion)
Result:Reduced the brain infarct volume in MCAO rats.
体外研究：
Cultures of the murine microglial cell line N9 and primary mixed glial cultures were used to test the drug effects of NO production upon expression of the inducible isoform of nitric oxide synthase (iNOS). Oxyresveratrol considerably diminished NO (nitrite) levels (IC50 of 45.31 μM) in murine microglial cells. Oxyresveratrol can inhibit DOPA oxidase activity, cyclooxygenase, and rat liver mitochondrial ATPase activity. Oxyresveratrol exhibits 63.3% inhibition at 100 μM and an IC50 value of 52.7 μM on the murine tyrosinase activity. Oxyresveratrol exhibits a dose-dependent inhibitory effect on L-tyrosine oxidation by the murine tyrosinase but does not inhibit the promoter activity of the enzyme gene. Oxyresveratrol exhibits significant inhibitory effects at 10 μM and higher concentrations on murine tyrosinase activity.
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects.
体内研究：
Oxyresveratrol (2-30 mg/kg; intraperitoneal injection; twice) treatment reduces the brain infarct volume in MCAO rats. Oxyresveratrol treatment diminishes cytochrome c release and decreased caspase-3 activation, and reduces the number of apoptotic nuclei in ischemic brain in MCAO rats.Animal Model:Adult male Wistar rats (300-350 g) with middle cerebral artery occlusion (MCAO)
Dosage:2 mg/kg, 10 mg/kg, 20 mg/kg and 30 mg/kg
Administration:Intraperitoneal injection; twice (at the time of occlusion and at the time of reperfusion)
Result:Reduced the brain infarct volume in MCAO rats.
体外研究：
Cultures of the murine microglial cell line N9 and primary mixed glial cultures were used to test the drug effects of NO production upon expression of the inducible isoform of nitric oxide synthase (iNOS). Oxyresveratrol considerably diminished NO (nitrite) levels (IC50 of 45.31 μM) in murine microglial cells. Oxyresveratrol can inhibit DOPA oxidase activity, cyclooxygenase, and rat liver mitochondrial ATPase activity. Oxyresveratrol exhibits 63.3% inhibition at 100 μM and an IC50 value of 52.7 μM on the murine tyrosinase activity. Oxyresveratrol exhibits a dose-dependent inhibitory effect on L-tyrosine oxidation by the murine tyrosinase but does not inhibit the promoter activity of the enzyme gene. Oxyresveratrol exhibits significant inhibitory effects at 10 μM and higher concentrations on murine tyrosinase activity.
产品资料
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