产品
编 号：F308522
分子式：C16H12O5
分子量：284.26
分子式：C16H12O5
分子量：284.26
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 29376-68-9
产品详情
生物活性：
Thevetiaflavone could upregulate the expression of Bcl-2 and downregulate that of Bax and caspase-3.
体外研究：
Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS-mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl-2 and downregulating that of Bax and caspase-3 in addition to increasing the activity of caspase-3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic.
Thevetiaflavone could upregulate the expression of Bcl-2 and downregulate that of Bax and caspase-3.
体外研究：
Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS-mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl-2 and downregulating that of Bax and caspase-3 in addition to increasing the activity of caspase-3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备