产品
编 号：F308519
分子式：C20H16N6
分子量：340.38
分子式：C20H16N6
分子量：340.38
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 293762-45-5
产品详情
生物活性：
Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.
体内研究：
Ro 90-7501 (5 μg/g；腹腔注射；每天；持续 21 天；雌性 BALB/c 裸鼠) 处理显著延缓肿瘤生长并显著减小肿瘤体积。Animal Model:Female BALB/c nude mice (8-week-old) with HeLa cells underirradiation
Dosage:5 μg/g
Administration:Intraperitoneal injection; daily; for 21 days
Result:Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group.
体外研究：
与对照 HeLa 和 ME-180 细胞相比，Ro 90-7501 显著增强了放射敏感性。Ro 90-7501 在照射后显著增加细胞凋亡和受损的细胞周期。Ro 90-7501 在照射后抑制 ATM 及其下游蛋白 (如 H2AX、Chk1 和 Chk2) 的磷酸化。 RO 90-7501 本身不影响 IFN-β 和 NFκB 启动子活性，但显著增强 poly I:C 诱导的 IFN-β 启动子激活并以剂量依赖性方式抑制 NF-κB 的激活。用 RO 90-7501 处理细胞可显著增强 poly I:C的抗病毒活性。
Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.
体内研究：
Ro 90-7501 (5 μg/g；腹腔注射；每天；持续 21 天；雌性 BALB/c 裸鼠) 处理显著延缓肿瘤生长并显著减小肿瘤体积。Animal Model:Female BALB/c nude mice (8-week-old) with HeLa cells underirradiation
Dosage:5 μg/g
Administration:Intraperitoneal injection; daily; for 21 days
Result:Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group.
体外研究：
与对照 HeLa 和 ME-180 细胞相比，Ro 90-7501 显著增强了放射敏感性。Ro 90-7501 在照射后显著增加细胞凋亡和受损的细胞周期。Ro 90-7501 在照射后抑制 ATM 及其下游蛋白 (如 H2AX、Chk1 和 Chk2) 的磷酸化。 RO 90-7501 本身不影响 IFN-β 和 NFκB 启动子活性，但显著增强 poly I:C 诱导的 IFN-β 启动子激活并以剂量依赖性方式抑制 NF-κB 的激活。用 RO 90-7501 处理细胞可显著增强 poly I:C的抗病毒活性。
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