产品
编 号：F036265
分子式：C24H31N5O4S2
分子量：517.66
分子式：C24H31N5O4S2
分子量：517.66
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
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25mg
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50mg
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结构图
CAS No: 1101810-02-9
产品详情
生物活性：
AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K.
体内研究：
The pharmacokinetic parameters of AZD3147.ParameterMouseDog
CL (mL/min/kg)7816
Vss (L/kg)2.32.2
t1/2(h)0.91.9
F%6173
体外研究：
AZD3147 (0-50 nM, 1 h) can alleviate fibroblast growth factor (FGF)-mediated cilia extension at concentrations above 1.5 nM in NIH3T3 cells. AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly and IMR-32 with the IC50 values of 0.88 nM and 662.4 nM, respectively.
AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K.
体内研究：
The pharmacokinetic parameters of AZD3147.ParameterMouseDog
CL (mL/min/kg)7816
Vss (L/kg)2.32.2
t1/2(h)0.91.9
F%6173
体外研究：
AZD3147 (0-50 nM, 1 h) can alleviate fibroblast growth factor (FGF)-mediated cilia extension at concentrations above 1.5 nM in NIH3T3 cells. AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly and IMR-32 with the IC50 values of 0.88 nM and 662.4 nM, respectively.
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