产品
编 号：F036258
分子式：C4H4O4
分子量：116.07
分子式：C4H4O4
分子量：116.07
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
10g
100
In-stock
25g
120
In-stock
结构图
CAS No: 110-17-8
产品详情
生物活性：
Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension.
体内研究：
Fumaric acid (10 mL/kg, 静脉注射) 通过下调 KCNMB1 和 TET1 的表达来治疗妊娠高血压。Animal Model:Gestational hypertension rat model
Dosage:10 mL/kg
Administration:i.v.
Result:Downregulated the levels of TET1 and KCNMB1.
体外研究：
Fumaric acid (50 μM, 24 h) 可抑制 p38 MAPK 依赖的 NF-κB 信号通路，减弱 TNF–α 刺激的成纤维细胞中 eotaxin-1 的表达。
Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension.
体内研究：
Fumaric acid (10 mL/kg, 静脉注射) 通过下调 KCNMB1 和 TET1 的表达来治疗妊娠高血压。Animal Model:Gestational hypertension rat model
Dosage:10 mL/kg
Administration:i.v.
Result:Downregulated the levels of TET1 and KCNMB1.
体外研究：
Fumaric acid (50 μM, 24 h) 可抑制 p38 MAPK 依赖的 NF-κB 信号通路，减弱 TNF–α 刺激的成纤维细胞中 eotaxin-1 的表达。
产品资料
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