产品
编 号：F307982
分子式：C23H34F3N5O7
分子量：549.54
分子式：C23H34F3N5O7
分子量：549.54
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 291778-77-3
产品详情
生物活性：
AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.
体内研究：
Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED50: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv.
体外研究：
AE-3763 exhibits potent in vitro inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water.
AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.
体内研究：
Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED50: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv.
体外研究：
AE-3763 exhibits potent in vitro inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water.
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