产品
编 号：F307669
分子式：C35H45Cl2NO6
分子量：646.64
分子式：C35H45Cl2NO6
分子量：646.64
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CAS No: 29069-24-7
产品详情
生物活性：
Prednimustine (Leo 1031;NSC 134087) is the ester formed from Prednisolone (HY-17463) and Chlorambucil (HY-13593). Prednimustine can be used for leukemias and lymphomas research.
体内研究：
Prednimustine (120 mg/kg; s.c.; single dose) shows much less toxic than equimolar doses of Chlorambucil (HY-13593) (60 mg/kg; s.c.; single dose) in non-tumour-bearing rat model, due to differences in alkylating agent pharmacokinetics.Prednimustine (40 mg/kg; s.c.; single dose) produces low plasma concentrations (less than 5 microM) of the alkylating metabolites chlorambucil and phenyl acetic mustard, which were maintained for 48 h in rats bearing the sensitive strain of the Walker 256 carcinosarcoma grown as an ascites.Prednimustine (40 mg/kg;s.c.; single dose; measured at 72 h) shows antitumor effect in rats model with the alkylating agent-resistant strain of the Yoshida sarcoma.Animal Model:Female Wistar rats non-tumour-bearing (150-200g)
Dosage:120 mg/kg
Administration:Subcutaneous injection; single dose; observed at day 21
Result:Remained 100% survival of rats, while 0% survival for Chlorambucil treatment group.
Animal Model:Female Wistar rats bearing the alkylating agent-resistant strain of the Yoshida sarcoma (150-200g)
Dosage:40 mg/kg
Administration:Subcutaneous injection; single dose
Result:Killed 57% of the resistant tumour cells.
Prednimustine (Leo 1031;NSC 134087) is the ester formed from Prednisolone (HY-17463) and Chlorambucil (HY-13593). Prednimustine can be used for leukemias and lymphomas research.
体内研究：
Prednimustine (120 mg/kg; s.c.; single dose) shows much less toxic than equimolar doses of Chlorambucil (HY-13593) (60 mg/kg; s.c.; single dose) in non-tumour-bearing rat model, due to differences in alkylating agent pharmacokinetics.Prednimustine (40 mg/kg; s.c.; single dose) produces low plasma concentrations (less than 5 microM) of the alkylating metabolites chlorambucil and phenyl acetic mustard, which were maintained for 48 h in rats bearing the sensitive strain of the Walker 256 carcinosarcoma grown as an ascites.Prednimustine (40 mg/kg;s.c.; single dose; measured at 72 h) shows antitumor effect in rats model with the alkylating agent-resistant strain of the Yoshida sarcoma.Animal Model:Female Wistar rats non-tumour-bearing (150-200g)
Dosage:120 mg/kg
Administration:Subcutaneous injection; single dose; observed at day 21
Result:Remained 100% survival of rats, while 0% survival for Chlorambucil treatment group.
Animal Model:Female Wistar rats bearing the alkylating agent-resistant strain of the Yoshida sarcoma (150-200g)
Dosage:40 mg/kg
Administration:Subcutaneous injection; single dose
Result:Killed 57% of the resistant tumour cells.
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