产品
编 号:F036179
分子式:C19H35N3O4S
分子量:401.56
产品类型
结构图
CAS No: 110115-07-6
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生物活性:
ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI).
体内研究:
ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death.ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI).Animal Model:Adult male Wistar rats (280-300g) (spinal cord injury model)
Dosage:0.05, 0.5, and 2.5 mg/kg
Administration:Intraperitoneally; every 24 h for 1 week
Result:Showed significantly better motor function.