产品
编 号：F306629
分子式：C14H16O3
分子量：232.28
分子式：C14H16O3
分子量：232.28
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
244
In-stock
5mg
640
In-stock
10mg
960
In-stock
20mg
1600
In-stock
结构图
CAS No: 28808-62-0
产品详情
生物活性：
Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1.
体内研究：
与对照组相比，Fraxinellone (口服灌胃；30 和 100 mg/kg；每三天；30 天) 显著抑制女性无胸腺 BALB/c 裸体中的肿瘤生长，减少 HIF-1α、pTyr705 STAT3、PD-L1 和 VEGF 染色老鼠。Animal Model:BALB/c nude mice
Dosage:30 and 100?mg/kg
Administration:Oral gavage; 30 and 100?mg/kg; every three days; 30 days
Result:Significantly suppressed tumor growth.
体外研究：
Fraxinellone (0-100 μM；12 小时) 使 A549 细胞中 PD-L1 阳性细胞的百分比从 20.4% 降低到 11.4%。
Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1.
体内研究：
与对照组相比，Fraxinellone (口服灌胃；30 和 100 mg/kg；每三天；30 天) 显著抑制女性无胸腺 BALB/c 裸体中的肿瘤生长，减少 HIF-1α、pTyr705 STAT3、PD-L1 和 VEGF 染色老鼠。Animal Model:BALB/c nude mice
Dosage:30 and 100?mg/kg
Administration:Oral gavage; 30 and 100?mg/kg; every three days; 30 days
Result:Significantly suppressed tumor growth.
体外研究：
Fraxinellone (0-100 μM；12 小时) 使 A549 细胞中 PD-L1 阳性细胞的百分比从 20.4% 降低到 11.4%。
产品资料
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